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Magic™ Antibody Discovery - Human Insulin R / CD220 (28-944) Membrane Protein, Partial, -His tag (CAT#: MP0303F)

Datasheet
This membrane protein is Human Insulin R / CD220 (28-944). It has been tested in SDS-PAGE, ELISA, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Insulin R / CD220
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 106.5 kDa. The protein migrates as 115-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA His 28 - Lys 944 (Accession # P06213-2).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SPR
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Insulin R / CD220
  • Full Name
  • insulin receptor
  • Introduction
  • This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • HHF5; CD220; insulin receptor; IR

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