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Magic™ Antibody Discovery - Human JAK1 (561-852) Membrane Protein, Partial, His- tag (CAT#: MP0882F)

Datasheet
This membrane protein is Human JAK1 (30-282). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • JAK1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 35.7 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Ala 561 - Asn 852 (Accession # P23458-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • Baculovirus-Insect cells
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Delivered as bulk protein in a 0.2 μm filtered solution of 50 mM Tris, 500 mM NaCl, 2 mM TCEP, pH8.0 with glycerol as protectant.

Target

  • Target Protein
  • JAK1
  • Full Name
  • Janus kinase 1
  • Introduction
  • This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • JTK3; AIIDE; JAK1A; JAK1B; tyrosine-protein kinase JAK1

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