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Magic™ Antibody Discovery - Human Latent TGF-beta 1 / TGFB1 (30-390) Membrane Protein, Partial, His- tag (CAT#: MP0575F)

Datasheet
This membrane protein is Human Latent TGF-beta 1 / TGFB1 (30-390). It has been tested in SDS-PAGE, ELISA, Cell based assay. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Latent TGF-beta 1 / TGFB1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 42.6 kDa (monomer). The protein migrates as 37-45 kDa (LAP) and 13 kDa (TGFB1) under reducing (R) condition (SDS-PAGE) due to glycosylation and Interchain disulfide bond.
  • Sequence
  • AA Leu 30 - Ser 390 (Accession # P01137-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, Cell based assay
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Latent TGF-beta 1 / TGFB1
  • Full Name
  • transforming growth factor beta 1
  • Introduction
  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
  • Alternative Names
  • CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1; transforming growth factor beta-1 proprotein; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1; transforming growth factor beta1

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