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Magic™ Antibody Discovery - Human LIF R / CD118 (45-833) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0567F)

Datasheet
This membrane protein is Human LIF R / CD118 (45-833). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • LIF R / CD118
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 115.5 kDa. The protein migrates as 140-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 45 - Ser 833 (Accession # P42702-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • LIF R / CD118
  • Full Name
  • LIF receptor subunit alpha
  • Introduction
  • This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.
  • Alternative Names
  • SWS; SJS2; STWS; CD118; LIF-R; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor alpha; leukemia inhibitory factor receptor alpha

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