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Magic™ Antibody Discovery - Human Netrin receptor DCC / DCC (32-1097) Membrane Protein, Partial, -His tag (CAT#: MP0723F)

This membrane protein is Human Netrin receptor DCC / DCC (32-1097). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Netrin receptor DCC / DCC
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 119.5 kDa
  • Sequence
  • AA Phe 32 - Asn 1097 (Accession # P43146-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Buffer
  • Please contact us for detailed information.

    Contact us for customized product form or formulation.

Target

  • Target Protein
  • Netrin receptor DCC / DCC
  • Full Name
  • DCC netrin 1 receptor
  • Introduction
  • This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
  • Alternative Names
  • CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1; netrin receptor DCC; colorectal cancer suppressor; deleted in colorectal carcinoma; immunoglobulin superfamily DCC subclass member 1; putative colorectal tumor suppressor; tumor suppressor protein DCC

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