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Magic™ Antibody Discovery - Human PCSK9 (31-692) Membrane Protein, Partial, -mIgG2a Fc tag (CAT#: MP0758F)

Datasheet
This membrane protein is Human PCSK9 (31-692). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PCSK9
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 98.0 kDa.
  • Sequence
  • AA Gln 31 - Gln 692 (Accession # Q8NBP7-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Mouse IgG2a Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Buffer
  • Please contact us for detailed information.

    Contact us for customized product form or formulation.

Target

  • Target Protein
  • PCSK9
  • Full Name
  • proprotein convertase subtilisin/kexin type 9
  • Introduction
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; proprotein convertase subtilisin/kexin type 9; convertase subtilisin/kexin type 9 preproprotein; neural apoptosis regulated convertase 1; subtilisin/kexin-like protease PC9

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