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Magic™ Antibody Discovery - Human PD-L1 / B7-H1 Membrane Protein, Partial, -mIgG1 Fc tag, low endotoxin (CAT#: MP1461F)

Datasheet
This membrane protein is Human PD-L1 / B7-H1 (19-238). It has been tested in SDS-PGAE, SEC-HPLC, ELISA, BLI, FACS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PD-L1 / B7-H1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 51.4 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Phe 19 - Arg 238 (Accession # NP_054862.1)

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PGAE, SEC-HPLC, ELISA, BLI, FACS
  • Expression Systems
  • HEK293
  • Tag
  • Mouse IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, (pH7.5). Trehalose is added as protectant before lyophilization.

    Please contact us for customized formulation or product form if needed.

Target

  • Target Protein
  • PD-L1 / B7-H1
  • Full Name
  • CD274 molecule
  • Introduction
  • This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1

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