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Magic™ Antibody Discovery - Human RIIB / ACVR2B (19-137) Membrane Protein, Partial, -His tag (CAT#: MP0921F)

Datasheet
This membrane protein is Human RIIB / ACVR2B (24-126). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • RIIB / ACVR2B
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 14.5 kDa. The protein migrates as 25-40 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Ser 19 - Thr 137 (Accession # Q13705-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >97% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • RIIB / ACVR2B
  • Full Name
  • activin A receptor type 2B
  • Introduction
  • Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
  • Alternative Names
  • HTX4; ACTRIIB; ActR-IIB; activin receptor type-2B; activin A receptor, type IIB
  • Gene ID
  • 93

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