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Magic™ Antibody Discovery - Human TIMP1 (24-207) Membrane Protein, Partial, -His tag (CAT#: MP0491F)

Datasheet
This membrane protein is Human TIMP1 (24-207). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TIMP1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 21.5 kDa. The protein migrates as 30-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Cys 24 - Ala 207 (Accession # P01033-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by reduced SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • TIMP1
  • Full Name
  • TIMP metallopeptidase inhibitor 1
  • Introduction
  • This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
  • Alternative Names
  • EPA; EPO; HCI; CLGI; TIMP; TIMP-1; metalloproteinase inhibitor 1; collagenase inhibitor; epididymis secretory sperm binding protein; erythroid potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1

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