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Magic™ Antibody Discovery - Human Transthyretin / Prealbumin (21-147) Membrane Protein, Partial, -His tag (CAT#: MP0463F)

Datasheet
This membrane protein is Human Transthyretin / Prealbumin (21-147). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Transthyretin / Prealbumin
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 14.9 kDa. The protein migrates as 19 kDa and 37 kDa under reducing (R) condition (SDS-PAGE) due to the monomer and dimer respectively.
  • Sequence
  • AA Gly 21 - Glu 147 (Accession # NP_000362).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Transthyretin / Prealbumin
  • Full Name
  • transthyretin
  • Introduction
  • This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.
  • Alternative Names
  • CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651; transthyretin; epididymis luminal protein 111; prealbumin, amyloidosis type I; thyroxine-binding prealbumin

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