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Magic™ Antibody Discovery - Human TrkA / NTRK1 (192-402) (192-402) Membrane Protein, Partial, -mIgG2a Fc tag (CAT#: MP0471F)

Datasheet
This membrane protein is Human TrkA / NTRK1 (192-402) (192-402). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TrkA / NTRK1 (192-402)
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 49.1 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gly 192 - Val 402 (Accession # P04629-2).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Mouse IgG2a Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by reduced SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • TrkA / NTRK1 (192-402)
  • Full Name
  • neurotrophic receptor tyrosine kinase 1
  • Introduction
  • This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
  • Alternative Names
  • MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; Oncogene TRK; TRK1-transforming tyrosine kinase protein; gp140trk; neurotrophic tyrosine kinase, receptor, type 1; tropomyosin-related kinase A; tyrosine kinase receptor A

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