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Magic™ Antibody Discovery - Mouse Her2 / ErbB2 (23-653) Membrane Protein, Partial, -His tag (CAT#: MP0206F)

Datasheet
This membrane protein is Mouse Her2 / ErbB2 (23-653). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • Her2 / ErbB2
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 70.6 kDa. The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Thr 23 - Thr 653 (Accession # AAH53078.1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Her2 / ErbB2
  • Full Name
  • erb-b2 receptor tyrosine kinase 2
  • Introduction
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
  • Alternative Names
  • Ne; HER; Neu; HER-; HER2; c-ne; ErbB-; HER-2; c-neu; l11Ju; Erbb-2; c-erbB; c-erbB2; l11Jus8; mKIAA3023; receptor tyrosine-protein kinase erbB-2; Neu oncogene; avian erythroblastosis oncogene B 2; c-erbB-2; p185erbB2; proto-oncogene NEU; proto-oncogene c-ErbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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