Magic™ Antibody Discovery - Rat IL-2 R beta&IL-2 R gamma (27-239(IL-2RB)&25-262 (IL-2RG)) Membrane Protein, Partial, -His tag & -StrepII tag (CAT#: MPX4724K)

Datasheet

This membrane protein is Rat IL-2 R beta&IL-2 R gamma. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

Host Species
Rat

Target Protein
IL-2 R beta&IL-2 R gamma

Protein Length
ECD

Protein Class
Receptor

Molecular Weight
30.2 kDa (IL-2RB) and 34.7 kDa (IL-2RG)

Sequence
AA Ala 27 - Glu 239 (IL-2RB) & Ser 25 - Ala 262 (IL-2RG) (Accession # P26896-1(IL-2RB) & Q68FU6-1(IL-2RG))

Product Description

Activity
Yes

Expression Systems
HEK293

Tag
Subunit IL-2RB is fused with a His tag at the C-terminus and subunit IL-2RG is fused with a StrepII tag at the C-terminus.

Protein Format
Soluble

Reconstitution
Please see Certificate of Analysis for specific instructions.

Endotoxin
<1.0 EU per μg by the LAL method

Purity
>95% as determined by SDS-PAGE.

Buffer
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4

Target

Target Protein
IL-2 R beta&IL-2 R gamma

Full Name
Interleukin 2 receptor subunit beta & Interleukin 2 receptor subunit gamma

Introduction
Enables interleukin-2 binding activity and interleukin-2 receptor activity. Involved in cytokine-mediated signaling pathway and natural killer cell activation. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta).
Predicted to enable interleukin-15 receptor activity and interleukin-2 binding activity. Predicted to be involved in interleukin-15-mediated signaling pathway and positive regulation of phagocytosis. Predicted to act upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Used to study X-linked severe combined immunodeficiency and combined T cell and B cell immunodeficiency. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).

Alternative Names
IL-2 R beta & IL-2 R gamma, IL-2RB & IL-2RG

Gene ID
25746 & 140924

UniProt ID
P26896 & Q68FU6

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