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Magic™ Antibody Discovery - Rhesus macaque CD40 / TNFRSF (21-193) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP1137F)

Datasheet
This membrane protein is Rhesus macaque CD40 / TNFRSF (21-193). It has been tested in SDS-PAGE, ELISA, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Rhesus macaque
  • Target Protein
  • CD40 / TNFRSF
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 45.9 kDa. The protein migrates as 56 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Glu 21 - Arg 193 (Accession # NP_001252791.1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, BLI
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CD40 / TNFRSF
  • Full Name
  • CD40 ligand
  • Introduction
  • This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Alternative Names
  • CD40L; CD40 ligand; CD154 protein; CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome); CD40-L; tumor necrosis factor ligand superfamily member 5

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