Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsPowered by our advanced high-resolution Magic™ sequencing platform and experienced technical personnel, Creative Biolabs can provide high-quality service of T cell receptor (TCR) repertoire profiling in canine. Our seasoned scientists have developed a set of primers which is specific to capture TCRs in canine. We are proud to share our experience in TCR repertoire analysis in canine to help our clients’ related projects development.
The Properties of TCR in Canine
In canine, T cell receptor beta (TRB) locus consists of a library of 37 TRBV genes positioned at the 5' end of two in tandem aligned D-J-C gene clusters. Each of them is composed of a single TRBD, 6 TRBJ, and one TRBC genes, followed by a single TRBV gene with an inverted transcriptional orientation. The TRB genes are distributed in less than 300 kb, making the canine locus, one of the smaller mammalian TRB locus studied so far. Reduced gene duplication occurrences and a lower density of total interspersed repeats compared to humans and mice may result in the small size. Despite the low TRBV gene content, a large and diversified beta chain repertoire is displayed in the canine peripheral blood. A full usage of TRBV and TRBJ genes, including pseudogenes, and a high level of allelic polymorphism contribute to generating diversity. The evolutionary conservation of TCR locus in canine makes it a highly suitable model system for immune development and diseases.
Canine TCR Repertoire Profiling in Creative Biolabs
Unbiased dissection of TCR repertoire diversity at the nucleotide level could provide important insights into canine immunity. With the latest instruments and professional staffs, Creative Biolabs is dedicated to offering first-class repertoire analysis service in a time-saving manner. Through our Magic™ TCR repertoire analysis platform, we have developed an advanced method to conduct a comprehensive TCR repertoire analysis in canine. Our scientists have performed over hundreds of TCR repertoire sequencing projects and accumulated sufficient experience.
Key Advantages of Canine TCR Repertoire Profiling Service
With years of research and development experience in the field of immunology, Creative Biolabs has owned a group of scientists who have the distinguished understanding of the adaptive immune system. Through the one-stop TCR repertoires analysis platform, our seasoned scientists can provide the best service of TCR repertoire profiling in canine at the most competitive cost.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
