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Magic™ Human CD38 E.G7-OVA Cell Line (CAT#: S01YF-0324-KX70)

This product is a E.G7-OVA stable cell line. It stably expresses Human CD38 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • CD38
  • Target Protein Species
  • Human
  • Host Cell Type
  • E.G7-OVA
  • Target Classification
  • Immune Checkpoint
  • Target Family
  • Immune Checkpoint
  • Target Research Area
  • Autoimmune Research; Immunology Research
  • Related Diseases
  • Leukemia; Prolymphocytic Leukemia

Product Properties

  • Assay Types
  • Functional assay and biological assay
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Form
  • Frozen cells
  • Freeze Medium
  • 70% RPMI 1640 + 20% FBS + 10% DMSO
  • Culture Medium
  • RPMI 1640 + 10% FBS
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • CD38 molecule
  • Introduction
  • The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • CD38; ADPRC1; ADPRC 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; CD38 antigen (p45); NAD(+) nucleosidase; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; CD38 molecule
  • Gene ID
  • 952
  • UniProt ID
  • P28907

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