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Magic™ Human MET CT26 Cell Line (CAT#: S01YF-0324-KX44)

This product is a CT26 stable cell line. It stably expresses Human MET to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • MET
  • Target Protein Species
  • Human
  • Host Cell Type
  • CT26
  • Target Classification
  • Kinases/Enzyme
  • Target Family
  • Kinases/Enzyme
  • Target Research Area
  • Cancer Research; Digestive and Renal Research; Reproductive Research; Auditory and Otology Research
  • Related Diseases
  • Renal Cell Carcinoma, Papillary; Deafness, Autosomal Recessive

Product Properties

  • Assay Types
  • Functional assay and biological assay
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Expression verification
  • Form
  • Frozen cells
  • Freeze Medium
  • DMEM + 20% FBS + 10% DMSO
  • Culture Medium
  • DMEM + 10% FBS
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • MET proto-oncogene, receptor tyrosine kinase
  • Introduction
  • This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
  • Alternative Names
  • MET; HGFR; AUTS9; RCCP2; c-Met; DFNB97; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; MET proto-oncogene, receptor tyrosine kinase
  • Gene ID
  • 4233
  • UniProt ID
  • P08581

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