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Magic™ Human S1PR1 U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay (CAT#: S01YF-1222-KX51)

Datasheet
This product is a U2OS GPCR stable cell line. It can be applied in high-throughput drug screening and functional assays.

Product Information

  • Target Protein
  • S1PR1
  • Target Protein Species
  • Human
  • Accession Number
  • NM_001400.2
  • Host Cell Type
  • U2OS
  • Target Classification
  • GPCR
  • Target Family
  • Lysophospholipid Receptor
  • Target Research Area
  • Autoimmune Research; Inflammation Research; Cardiovascular Research
  • Related Diseases
  • Autoimmune Encephalitis; Herpes Zoster Oticus

Product Properties

  • Assay Types
  • Reporter Assay
  • Assay Reporter
  • BLA (Beta-Lactamase)
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 2x10⁶ cells
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Sphingosine-1-phosphate receptor 1
  • Introduction
  • The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants.
  • GPCR Signaling Pathway
  • The endogenous ligand is sphingosine-1-phosphate. Targeted protein activation can cause binding of Gi to Go protein which, in turn, cause an inhibition of adenylate cyclase and then decrease of cAMP concentration.
  • Endogenous Ligand
  • Sphingosine-1-phosphate
  • Alternative Names
  • EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362; sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; S1PR1; Sphingosine-1-phosphate receptor 1

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