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Magic™ Human TLR8 HEK293 Cell Line with SEAP Reporter (CAT#: S01YF-0123-KX407)

Datasheet
This product is a HEK293 stable cell line. It stably expresses Human TLR8 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • TLR8
  • Target Protein Species
  • Human
  • Host Cell Type
  • HEK293
  • Target Classification
  • Immune Checkpoint
  • Target Family
  • Immune Checkpoint
  • Target Research Area
  • Autoimmune Research; Immunology Research
  • Related Diseases
  • Immunodeficiency; Anemia, Autoimmune Hemolytic

Product Properties

  • Morphology
  • Adherent
  • Assay Types
  • Drug screening and biological assays
  • Assay Reporter
  • SEAP
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 3x10⁶ cells
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Toll like receptor 8
  • Introduction
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
  • Alternative Names
  • TLR8; CD288; toll-like receptor 8; Toll like receptor 8

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