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Magic™ Human TNFRSF18 HT1080 Cell Line (CAT#: S01YF-0123-KX351)

Datasheet
This product is a HT1080 stable cell line. It stably expresses Human TNFRSF18 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • TNFRSF18
  • Target Protein Species
  • Human
  • Accession Number
  • NM_004195.2
  • Protein Tag
  • Tag-free
  • Host Cell Type
  • HT1080
  • Target Classification
  • Immune Checkpoint
  • Target Family
  • Immune Checkpoint
  • Target Research Area
  • Autoimmune Research; Immunology Research
  • Related Diseases
  • Immunodysregulation; Polyendocrinopathy; Enteropathy; X-Linked and Diverticulitis

Product Properties

  • Morphology
  • Epithelial
  • Assay Types
  • Drug screening and biological assays
  • Resistance
  • Puromycin
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • 10 passages
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 5x10⁶ cells
  • Form
  • Frozen cells
  • Freeze Medium
  • 70% RPMI 1640 + 20% FBS + 10% DMSO
  • Culture Medium
  • RPMI 1640 + 10% FBS + 0.5µg/mL Puromycin
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • TNF receptor superfamily member 18
  • Introduction
  • This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Alternative Names
  • TNFRSF18; AITR; GITR; CD357; GITR-D; ENERGEN; tumor necrosis factor receptor superfamily member 18; TNF receptor superfamily activation-inducible protein; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily member 18

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