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Magic™ Membrane Protein Human ABCA4 (ATP binding cassette subfamily A member 4) Full Length (CAT#: MPC0367K) Made to Order

Datasheet
This product is a 255.9 kDa Human ABCA4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ABCA4
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 255.9 kDa
  • TMD
  • 12
  • Sequence
  • MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYS
    HHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNS
    ILARVYRDFQELLMNAPESQHLGRIWTELHILSQFMDTLRTHPERIAGRG
    IRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQVRPEQFAHGVPDLAL
    KDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLYANVDF
    FKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVT
    RPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLG
    IDSTRKDPIYSYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILY
    TPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNM
    IRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWR
    DIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAG
    VVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVED
    FRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMII
    LNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTW
    FLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFL
    LSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPV
    AFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVY
    GLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPL
    TEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLN
    ITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDA
    VRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTG
    LHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSI
    WDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNC
    FGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQV
    LDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFREL
    EETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPR
    HPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQL
    VLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEY
    PALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWL
    PEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLP
    ECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKF
    WVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASK
    EIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPE
    EYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLY
    LIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQ
    KKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANL
    FIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLAL
    SQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHF
    FLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGT
    SSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAG
    KSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKV
    ANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTG
    MDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRC
    MGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRE
    RHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAK
    QQTESHDLPLHPRAAGASRQAQD

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ABCA4
  • Full Name
  • ATP binding cassette subfamily A member 4
  • Introduction
  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, and the gene product mediates transport of an essental molecule, all-trans-retinal aldehyde (atRAL), across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.
  • Alternative Names
  • FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1; retinal-specific phospholipid-transporting ATPase ABCA4; ATP binding cassette transporter; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding transporter, retina-specific; RIM ABC transporter; RIM protein; photoreceptor rim protein; retina-specific ABC transporter; retinal-specific ATP-binding cassette transporter; stargardt disease protein; ABCA4; ATP binding cassette subfamily A member 4
  • Gene ID
  • 24

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