Magic™ Membrane Protein Human ABCC1 (ATP binding cassette subfamily C member 1) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, Partial (1248-1531aa) (CAT#: MPX4277K)

Datasheet

This product is a 35.9 kDa Human ABCC1 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
ABCC1

Protein Length
Partial (1248-1531aa)

Protein Class
Transporter

Molecular Weight
35.9 kDa

Sequence
VRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAkDaGLV

Product Description

Expression Systems
E.coli

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
ABCC1

Full Name
ATP binding cassette subfamily C member 1

Introduction
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

Alternative Names
MRP; ABCC; GS-X; MRP1; ABC29; DFNA77; multidrug resistance-associated protein 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant; ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; LTC4 transporter; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; ABCC1; ATP binding cassette subfamily C member 1

Gene ID
4363

UniProt ID
P33527

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