Close
Close

Magic™ Membrane Protein Human ABCC5 (ATP binding cassette subfamily C member 5) Full Length (CAT#: MPC0355K) Made to Order

Datasheet
This product is a 160.6 kDa Human ABCC5 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ABCC5
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 160.6 kDa
  • TMD
  • 13
  • Sequence
  • MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDAL
    ETAARAEGLSLDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHP
    VDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLE
    RLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFM
    VKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRL
    RGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG
    PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAA
    TDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQS
    ITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVT
    PFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWD
    SSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLL
    LDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG
    KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYD
    EERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALY
    SDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDC
    DEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKET
    SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYI
    QAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS
    VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDE
    LFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILV
    FFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPF
    LSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAV
    RLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLA
    SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM
    RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGC
    IKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIW
    DALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKI
    LILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVL
    AQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ABCC5
  • Full Name
  • ATP binding cassette subfamily C member 5
  • Introduction
  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145; multidrug resistance-associated protein 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; canalicular multispecific organic anion transporter C; multi-specific organic anion transporter C; ABCC5; ATP binding cassette subfamily C member 5

Customer reviews and Q&As    

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us