Magic™ Membrane Protein Human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase) Expressed in CHO for Antibody Discovery, Partial (63-354aa) (CAT#: MPX0773K)

Datasheet

This product is a 34.8 kDa Human ABO membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
ABO

Protein Length
Partial (63-354aa)

Protein Class
Transferase

Molecular Weight
34.8 kDa

Sequence
RVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTV
FAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVGAYKR
WQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPSFYGSS
REAFTYERRPQSQAYIPKDEGDFYYMGAFFGGSVQEVQRLTRACHQAMMVDQANGIEAVW
HDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP

Product Description

Activity
Yes

Expression Systems
CHO

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Endotoxin
<1.0 EU per 1 μg of the protein by the LAL method.

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane.

Buffer
Supplied as a 0.2 μm filtered solution in Tris and NaCl.

Target

Target Protein
ABO

Full Name
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Introduction
This gene encodes proteins related to the first discovered blood group system, ABO. Variation in the ABO gene (chromosome 9q34.2) is the basis of the ABO blood group, thus the presence of an allele determines the blood group in an individual. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. This locus has been identified as a susceptibility locus for severe coronavirus disease 2019 (COVID-19) by genome-wide association study.

Alternative Names
ABO; GTB; NAGAT; A3GALNT; A3GALT1; histo-blood group ABO system transferase; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase); B(A) alpha-1,3-galactosyltransferase; histo-blood group A2 transferase; ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Gene ID
28

UniProt ID
P16442

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