Magic™ Membrane Protein Human ADGRE5 (Adhesion G protein-coupled receptor E5) Expressed in CHO for Antibody Discovery, Partial (21-398aa) (CAT#: MPX0174K)

Datasheet

This product is a 42 kDa Human ADGRE5 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
ADGRE5

Protein Length
Partial (21-398aa)

Protein Class
GPCR

Molecular Weight
42 kDa

Sequence
QDSRGCARWCPQNSSCVNATACRCNPGFSS
FSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPV
SGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKF
IPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPN
GPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNN
QKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN
VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPF
TYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAV

Product Description

Expression Systems
CHO

Tag
6xHis tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 500 μg/mL in PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Target

Target Protein
ADGRE5

Full Name
Adhesion G protein-coupled receptor E5

Introduction
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.

Alternative Names
ADGRE5; CD97; TM7LN1; CD97 molecule; leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation; Adhesion G protein-coupled receptor E5

Gene ID
976

UniProt ID
P48960

Customer reviews and Q&As Write a review Ask a question

Related Products

Online Inquiry

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: