Close
Close

Magic™ Membrane Protein Human ADORA2A (Adenosine A2a receptorperoxisome proliferator activated receptor gamma) (CAT#: MP0037F)

Datasheet
Adenosine receptor A2A aids in the discovery, development, and validation of new molecules as well as therapeutic antibodies. They are ideal for CNS neuroprotection in order to develop new treatments for insomnia, pain, depression, Alzheimer and Parkinson's diseases.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADORA2A
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR Class A
  • Molecular Weight
  • 47.7kDa
  • TMD
  • 7
  • Sequence
  • MWSHPQFEKHHHHHHHHENLYFQGPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNY
    FVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGL
    VTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
    NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPL
    HIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAG
    TSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDV
    ELLSHELKGVCPEPPGLDDPLAQDGAGVS

Product Description

  • Activity
  • Confirmed by radiobinding assay
  • Expression Systems
  • Sf9
  • Tag
  • His/Strep (both N-terminal)​
  • Purification
  • Immobilized Metal Affinity Chromatography
  • Purity
  • >90%
  • Buffer
  • 50mM Hepes pH 7.4, 200mM NaCl, 0.05%/0.006% DDM/CHS

Target

  • Target Protein
  • ADORA2A
  • Full Name
  • Adenosine A2a receptorperoxisome proliferator activated receptor gamma
  • Introduction
  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.
  • Alternative Names
  • A2aR, RDC8, ADORA2

Customer reviews and Q&As    

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2025 Creative Biolabs. | Contact Us