Magic™ Membrane Protein Human ANPEP (Alanyl aminopeptidase, membrane) Expressed in E.coli with 10xHis and GST tag at the N-terminus, Myc tag at the C-terminus for Antibody Discovery, Partial (34-219aa) (CAT#: MPX4166K)

Datasheet

This product is a 55.8 kDa Human ANPEP membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
ANPEP

Protein Length
Partial (34-219aa)

Protein Class
Receptor

Molecular Weight
55.8 kDa

Sequence
SQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARK

Product Description

Expression Systems
E.coli

Tag
10xHis and GST tag at the N-terminus, Myc tag at the C-terminus

Protein Format
Soluble

Purity
>85% as determined by SDS-PAGE.

Buffer
Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

Target Protein
ANPEP

Full Name
Alanyl aminopeptidase, membrane

Introduction
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.

Alternative Names
ANPEP; APN; CD13; LAP1; P150; PEPN; GP150; aminopeptidase N; AP-M; AP-N; alanyl (membrane) aminopeptidase; aminopeptidase M; hAPN; membrane alanyl aminopeptidase; microsomal aminopeptidase; myeloid plasma membrane glycoprotein CD13; Alanyl aminopeptidase, membrane

Gene ID
290

UniProt ID
P15144

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