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Magic™ Membrane Protein Human ANTXR1 (ANTXR cell adhesion molecule 1) Expressed in HEK293 for Antibody Discovery, Partial (33-321aa) (CAT#: MPX0417K)

Datasheet
This product is a 34 kDa Human ANTXR1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ANTXR1
  • Protein Length
  • Partial (33-321aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 34 kDa
  • TMD
  • 1
  • Sequence
  • EDGGPACYGGFDLYFILD
    KSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDRE
    QIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTD
    GELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFP
    VNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHAR
    NVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMN
    DGLSFISSSVIITTTHCSDGS

Product Description

  • Activity
  • Yes
  • Expression Systems
  • HEK293
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • ANTXR1
  • Full Name
  • ANTXR cell adhesion molecule 1
  • Introduction
  • This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
  • Alternative Names
  • ANTXR1; ATR; GAPO; TEM8; anthrax toxin receptor 1; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8; ANTXR cell adhesion molecule 1

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