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Magic™ Membrane Protein Human APH1A (Aph-1 homolog A, gamma-secretase subunit) Full Length (CAT#: MPC1470K) Made to Order

This product is a 28.9 kDa Human APH1A membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • APH1A
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 28.9 kDa
  • TMD
  • 7
  • Sequence
  • MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLAS
    VVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEG
    LASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIH
    GDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLT
    SGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCRRQED
    SRVMVYSALRIPPED

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • APH1A
  • Full Name
  • Aph-1 homolog A, gamma-secretase subunit
  • Introduction
  • This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
  • Alternative Names
  • APH1A; APH-1; APH-1A; CGI-78; 6530402N02Rik; gamma-secretase subunit APH-1A; APH1A gamma secretase subunit; anterior pharynx defective 1 homolog A; aph-1alpha; presenilin-stabilization factor; Aph-1 homolog A, gamma-secretase subunit

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