Magic™ Membrane Protein Human ASPH (Aspartate beta-hydroxylase) Expressed in E.coli with 6xHis and SUMO tag at the N-terminus for Antibody Discovery, Partial (75-270aa) (CAT#: MPX4482K)

Datasheet

This product is a 38.2kDa Human ASPH membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
ASPH

Protein Length
Partial (75-270aa)

Protein Class
Transporter

Molecular Weight
38.2kDa

Sequence
FDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSEPVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPDT

Product Description

Expression Systems
E.coli

Tag
6xHis and SUMO tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
ASPH

Full Name
Aspartate beta-hydroxylase

Introduction
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

Alternative Names
ASPH; AAH; BAH; HAAH; JCTN; FDLAB; junctin; CASQ2BP1; aspartyl/asparaginyl beta-hydroxylase; A beta H-J-J; ASP beta-hydroxylase; cardiac junctin; humbug; junctate; peptide-aspartate beta-dioxygenase; Aspartate beta-hydroxylase

Gene ID
444

UniProt ID
Q12797

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