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Magic™ Membrane Protein Human ATP13A5 (ATPase 13A5) Full Length (CAT#: MPC1175K) Made to Order

Datasheet
This product is a 137.3 kDa Human ATP13A5 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP13A5
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 137.3 kDa
  • TMD
  • 10
  • Sequence
  • MEENSKKDHRALLNQGEEDELEVFGYRDHNVRKAFCLVASVLTCGGLLLV
    FYWRPQWRVWANCIPCPLQEADTVLLRTTDEFQRYMRKKVFCLYLSTLKF
    PVSKKWEESLVADRHSVINQALIKPELKLRCMEVQKIRYVWNDLEKRFQK
    VGLLEDSNSCSDIHQTFGLGLTSEEQEVRRLVCGPNAIEVEIQPIWKLLV
    KQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSV
    KLHNLVEDHNKVQVTIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAV
    LIDGSCVVNEGMLTGESIPVTKTPLPQMENTMPWKCHSLEDYRKHVLFCG
    TEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFK
    FIVFLACLGVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAAL
    TIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWG
    TVPTADNCFQEAHSFASGQAVPWSPLCAAMASCHSLILLNGTIQGDPLDL
    KMFEGTAWKMEDCIVDSCKFGTSVSNIIKPGPKASKSPVEAIITLCQFPF
    SSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELRSY
    TVQGFRVIALAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKE
    TKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIIVEADEP
    EEFVPASVTWQLVENQETGPGKKEIYMHTGNSSTPRGEGGSCYHFAMSGK
    SYQVIFQHFNSLLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGD
    GANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCVPHLIREGRAALV
    SSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLTM
    SSTHAYPKLAPYRPAGQLLSPPLLLSIFLNSCFSCIVQISAFLYVKQQPW
    YCEVYQYSECFLANQSNFSTNVSLERNWTGNATLIPGSILSFETTTLWPI
    TTINYITVAFIFSKGKPFRKPIYTNYIFSFLLLAALGLTIFILFSDFQVI
    YRGMELIPTITSWRVLILVVALTQFCVAFFVEDSILQNHELWLLIKREFG
    FYSKSQYRTWQKKLAEDSTWPPINRTDYSGDGKNGFYINGGYESHEQIPK
    RKLKLGGQPTEQHFWARL

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP13A5
  • Full Name
  • ATPase 13A5
  • Introduction
  • This gene encodes a member of the P5 subfamily of P-type transport ATPases. P-type ATPases form a large superfamily of cation and lipid pumps that transport inorganic cations and other substrates across cell membranes. P5 ATPases are localized to membranes of the endoplasmic reticulum (ER) and serve many important functions including transport of cargo proteins to the Golgi, glycosylation and cell wall biosynthesis, control of protein insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) degradation, and sensitivity to unfolded protein response (UPR) activators. The encoded protein is organized into three cytoplasmic domains (A, P, and N) and two membrane-embedded domains (T and S). The N-domain binds ATP and serves as a built-in protein kinase, which phosphorylates the P-domain. The A-domain is an intrinsic protein phosphatase, which dephosphorylates the P-domain once during each catalytic cycle.
  • Alternative Names
  • ATP13A5; ATPase type 13A5; P5-ATPase; probable cation-transporting ATPase 13A5; UNQ488/PRO1004; P5-ATPase isoform 5; ATPase 13A5

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