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Magic™ Membrane Protein Human ATP8A2 (ATPase phospholipid transporting 8A2) Full Length (CAT#: MPC0407K) Made to Order

Datasheet
This product is a 133.5 kDa Human ATP8A2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP8A2
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 133.5 kDa
  • TMD
  • 10
  • Sequence
  • MLNGAGLDKALKMSLPRRSRIRSSVGPVRSSLGYKKAEDEMSRATSVGDQ
    LEAPARTIYLNQPHLNKFRDNQISTAKYSVLTFLPRFLYEQIRRAANAFF
    LFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVN
    KKKTIVLRNGMWHTIMWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMC
    YVETANLDGETNLKIRQGLSHTADMQTREVLMKLSGTIECEGPNRHLYDF
    TGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGHDTKLMQNST
    KAPLKRSNVEKVTNVQILVLFGILLVMALVSSAGALYWNRSHGEKNWYIK
    KMDTTSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMY
    YIGNDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIAGVTY
    GHFPELAREPSSDDFCRMPPPCSDSCDFDDPRLLKNIEDRHPTAPCIQEF
    LTLLAVCHTVVPEKDGDNIIYQASSPDEAALVKGAKKLGFVFTARTPFSV
    IIEAMGQEQTFGILNVLEFSSDRKRMSVIVRTPSGRLRLYCKGADNVIFE
    RLSKDSKYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLKVYQEAS
    TILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIK
    IWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDL
    GNLLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQ
    KSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNS
    DYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVN
    GFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYKIT
    QNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFV
    GNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWP
    TIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTL
    LEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSS
    LQQGVPHGYAFSQEEHGAVSQEEVIRAYDTTKKKSRKK

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP8A2
  • Full Name
  • ATPase phospholipid transporting 8A2
  • Introduction
  • The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with a syndrome (CAMRQ4) characterized by cerebellar ataxia and cognitive disabilities. In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • IB; ATP; ML-1; ATPIB; CAMRQ4; phospholipid-transporting ATPase IB; ATPase, aminophospholipid transporter, class I, type 8A, member 2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; P4-ATPase flippase complex alpha subunit ATP8A2; probable phospholipid-transporting ATPase IB; ATP8A2; ATPase phospholipid transporting 8A2

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