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Magic™ Membrane Protein Human BAK1 (BCL2 antagonist/killer 1) (CAT#: MP0004F)

Datasheet
Human Bak (hBak) is a multidomain proapoptotic member located in the outer mitochondrial membrane (OMM), containing a unique transmembrane domain located on the C-terminus part of the protein. Bak is a key regulator of programmed cell death and controls apoptosis through protein-protein interaction. It is a member of the Bcl-2 family of antiapoptotic and proapoptotic proteins.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BAK1
  • Protein Length
  • Truncated form
  • Protein Class
  • Transporter
  • Molecular Weight
  • 17 kDa
  • TMD
  • 1
  • Sequence
  • MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM
    VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATRPAA
    TPTACLRVASIGAVWWLFWASATVWPYTSTSMA

Product Description

  • Activity
  • Validated
  • Application
  • Protein delivery
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >61% by SDS-Page and Coomassie Blue staining
  • Buffer
  • PBS, Tris 50mM, pH 7.5, HEPES 50mM, pH 7.5

Target

  • Target Protein
  • BAK1
  • Full Name
  • BCL2 antagonist/killer 1
  • Introduction
  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
  • Alternative Names
  • BAK, CDN1, BCL2L7, BAK-LIKE

Customer reviews and Q&As    

Q&As

What are the roles of Bax and Bak in vivo?

The primary role of the executors Bax and Bak is to disrupt MOM to allow the release of pro-apoptotic factors into the cytoplasm.
2022-12-05

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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