Magic™ Membrane Protein Human BMPR1B (Bone morphogenetic protein receptor type 1B) Expressed in NS0 for Antibody Discovery, Partial (14-126aa) (CAT#: MPX0221K)

Datasheet

This product is a 40 kDa Human BMPR1B membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
BMPR1B

Protein Length
Partial (14-126aa)

Protein Class
Transferase

Molecular Weight
40 kDa

Sequence
KKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTD
GYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERN
ECNKDLHPTLPPLKNRDFVDGPIHHR

Product Description

Expression Systems
NS0

Tag
hIgG1 Fc and 6xHis tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Endotoxin
<1.0 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
BMPR1B

Full Name
Bone morphogenetic protein receptor type 1B

Introduction
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.

Alternative Names
BMPR1B; ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293; bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; activin receptor-like kinase 6; bone morphogenetic protein receptor, type IB; serine/threonine receptor kinase; Bone morphogenetic protein receptor type 1B

Gene ID
658

UniProt ID
O00238

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