Magic™ Membrane Protein Human CCR2b (C-C motif chemokine receptor 2 inform b) (CAT#: MP0008F)

Datasheet

Also called CCR2 is a member of the beta chemokine receptor family. This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.

Product Specifications

Host Species
Human

Target Protein
CCR2b

Protein Length
Full Length

Protein Class
Receptor

Molecular Weight
42 kDa

Sequence
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRRYLSVFFRKHITKRFCKQCPVFYRETVDGVTSTNTPSTGEQEVSAGL

Product Description

Activity
To be tested

Application
Screening & Display Technologies, Antibody development, Structural Biology

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>40% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
CCR2b

Full Name
C-C motif chemokine receptor 2 inform b

Introduction
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 4.

Alternative Names
CKR2, CCR-2, CCR2A, CCR2B, CD192, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2

Gene ID
729230

UniProt ID
P41597

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Q&As

Is CCR2b a target for lupus erythematosus?

A study based on computerized bioinformatics analysis suggests that CCR2 is a potential drug target for lupus erythematosus. The main basis is as follows:
(a) Included as CCLE-DEG (blood and skin) by microarray analysis. The observed upregulation in case vs. control (blood) and lesional vs. non-lesional (skin) are accompanied by low e-values of ≤ 0.05.
(b) Overexpressed in disease vs. control peripheral blood by RT-qPCR analysis, in a separate set of samples as those used in the microarray analysis.
(c) Enriched in lupus-related pathways and processes by ontology enrichment analyses.
(d) "Over-connected" functional molecule by interactome analysis.
(e) A reaction hub by network analysis.
(f) Mapped to chromosome 3 in an overlapping skin/blood transcriptional "hot spot" by chromosome mapping analysis.
(g) Targeted by drugs that are currently being used to treat other diseases such as inflammatory and immune diseases by drug target analysis.
2022-12-13

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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