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Magic™ Membrane Protein Human CDH1 (Cadherin 1) Expressed in HEK293 for Antibody Discovery, Partial (155-707aa) (CAT#: MPX0216K)

Datasheet
This product is a 61 kDa Human CDH1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CDH1
  • Protein Length
  • Partial (155-707aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 61 kDa
  • TMD
  • 1
  • Sequence
  • DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTP
    PVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILI
    TVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAI
    AYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADL
    QGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
    ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQY
    ILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFG
    VGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDR
    EDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTI
    FFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESI
    ILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQP
    VEAGLQI

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 250 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE with silver staining
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • CDH1
  • Full Name
  • Cadherin 1
  • Introduction
  • This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
  • Alternative Names
  • CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; cadherin-1; CAM 120/80; E-cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; cell-CAM 120/80; epididymis secretory sperm binding protein; epithelial cadherin; uvomorulin; Cadherin 1

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