Magic™ Membrane Protein Human CDH12 (Cadherin 12) Expressed in NS0 for Antibody Discovery, Partial (24-609aa) (CAT#: MPX0414K)

Datasheet

This product is a 92.5 kDa Human CDH12 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
CDH12

Protein Length
Partial (24-609aa)

Protein Class
Cell adhesion

Molecular Weight
92.5 kDa

Sequence
QPQPQQTLATEPRENVIHLPGQRSHFQ
RVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT
VFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKV
QDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVY
SILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLA
GTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ
NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEA
SNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVG
TIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRE
STAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCEN
AKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGI
ETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS
CNVEAIFLP

Product Description

Activity
Yes

Expression Systems
NS0

Tag
hIgG1 Fc and 6xHis tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

Buffer
Lyophilized from a 0.2 μm filtered solution in Tris-Citrate, NaCl and CaCl2.

Target

Target Protein
CDH12

Full Name
Cadherin 12

Introduction
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Alternative Names
CDH12; CDHB; cadherin-12; Br-cadherin; N-cadherin 2; brain-cadherin; cadherin, neural type, 2; neural type cadherin 2; neuronal cadherin 2; Cadherin 12

Gene ID
1010

UniProt ID
P55289

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