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Magic™ Membrane Protein Human CHRNA4 (Cholinergic receptor nicotinic alpha 4 subunit) Full Length (CAT#: MPC0463K) Made to Order

This product is a 69.9 kDa Human CHRNA4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CHRNA4
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 69.9 kDa
  • TMD
  • 4
  • Sequence
  • MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNK
    WSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRW
    DPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQ
    WTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQ
    LDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINL
    IIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS
    LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLD
    IVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQS
    LHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCR
    PPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAP
    EADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRS
    TKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR
    IFLWMFIIVCLLGTVGLFLPPWLAGMI

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Strep tag at the C-terminus
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • CHRNA4
  • Full Name
  • Cholinergic receptor nicotinic alpha 4 subunit
  • Introduction
  • This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; neuronal acetylcholine receptor subunit alpha-4; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; CHRNA4; Cholinergic receptor nicotinic alpha 4 subunit

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