Magic™ Membrane Protein Human CLEC4G (C-type lectin domain family 4 member G) Expressed in NS0 for Antibody Discovery, Partial (54-293aa) (CAT#: MPX0550K)

Datasheet

This product is a 27.8 kDa Human CLEC4G membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
CLEC4G

Protein Length
Partial (54-293aa)

Protein Class
Receptor

Molecular Weight
27.8 kDa

Sequence
SKASTER
AALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQE
SALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNNSCEPCPTSWLSFEGSCYFFS
VPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWV
DGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC

Product Description

Activity
Yes

Expression Systems
NS0

Tag
9xHis tag at the N-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Buffer
Lyophilized from a 0.2 μm filtered solution in Tris-Citrate and NaCl.

Target

Target Protein
CLEC4G

Full Name
C-type lectin domain family 4 member G

Introduction
This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Names
CLEC4G; LP2698; UNQ431; DTTR431; LSECtin; C-type lectin superfamily 4, member G; liver and lymph node sinusoidal endothelial cell C-type lectin; C-type lectin domain family 4 member G

Gene ID
339390

UniProt ID
Q6UXB4

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