Magic™ Membrane Protein Human CLEC7A (C-type lectin domain containing 7A) Expressed in NS0 for Antibody Discovery, Partial (66-201aa) (CAT#: MPX0617K)

Datasheet

This product is a 16.8 kDa Human CLEC7A membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
CLEC7A

Protein Length
Partial (66-201aa)

Protein Class
Receptor; Immunity

Molecular Weight
16.8 kDa

Sequence
TMGVLSSPCPPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGF
IVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVS
VIYDQLCSVPSYSICEKKFSM

Product Description

Activity
Yes

Expression Systems
NS0

Tag
10xHis tag at the N-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
CLEC7A

Full Name
C-type lectin domain containing 7A

Introduction
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Alternative Names
CLEC7A; BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12; C-type lectin domain family 7 member A; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin superfamily member 12; DC-associated C-type lectin 1; beta-glucan receptor; dectin-1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; C-type lectin domain containing 7A

Gene ID
64581

UniProt ID
Q9BXN2

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