Magic™ Membrane Protein Human CXCR4 (C-X-C motif chemokine receptor 4) (CAT#: MP0010F)

Datasheet

Human CXCR4 (C-X-C Chemokine Receptor type 4) is an α-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is essential for proper fetal development and is the major co-receptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1). Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. As most N-terminal domain of chemokine receptors are the ligand binding domain, the N-terminal domain of CXCR4 is the binding site for SDF-1.

Product Specifications

Host Species
Human

Target Protein
CXCR4

Protein Length
Full Length

Protein Class
Receptor

Molecular Weight
43 kDa

Sequence
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS

Product Description

Activity
Validated

Application
Screening & display technologies

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>70% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
CXCR4

Full Name
C-X-C motif chemokine receptor 4

Introduction
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative Names
FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, D2S201E

Gene ID
7852

UniProt ID
P61073

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Q&As

What is the role of CXCR4 in vivo?

During the early stages of development, SDF-1 and CXCR4 play a role in cell migration. Throughout life, especially in adulthood, SDF-1/CXCR4 signaling may influence stem cell migration from bone marrow or niches to repair damaged tissues. Increased numbers of CXCR4 cells may be associated with inflammation/normal stem cell migration and cancer/malignancy abnormalities.
2022-12-17

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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