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Magic™ Membrane Protein Human DCC (DCC netrin 1 receptor) Full Length (CAT#: MPC2084K) Made to Order

This product is a 158.4 kDa Human DCC membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DCC
  • Protein Length
  • Full length
  • Protein Class
  • Receptor
  • Molecular Weight
  • 158.4 kDa
  • TMD
  • 1
  • Sequence
  • MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAV
    TMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQ
    NILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVT
    AFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQIS
    RLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVV
    AIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV
    TDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEF
    ECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQC
    VAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWR
    PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTF
    RVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP
    PAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLA
    YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT
    QNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMT
    VNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLN
    PNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFN
    NAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGV
    QAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT
    TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKD
    LTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETI
    SGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKM
    ANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLV
    IIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRP
    PDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGS
    KSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSA
    IPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQS
    VSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLL
    PPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVP
    TAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • DCC
  • Full Name
  • DCC netrin 1 receptor
  • Introduction
  • This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
  • Alternative Names
  • DCC; CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1; netrin receptor DCC; colorectal cancer suppressor; deleted in colorectal carcinoma; immunoglobulin superfamily DCC subclass member 1; putative colorectal tumor suppressor; tumor suppressor protein DCC; DCC netrin 1 receptor

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