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Magic™ Membrane Protein Human DSC1 (Desmocollin 1) Full Length (CAT#: MPC3948K) Made to Order

This product is a made-to-order Human DSC1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DSC1
  • Protein Length
  • Full length
  • Protein Class
  • Cell adhesion
  • TMD
  • 1
  • Sequence
  • MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKV
    NLEECLKSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQ
    RREQQEIKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGP
    FPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSI
    DREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFT
    VPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT
    GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDN
    PPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNEN
    GNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQT
    PTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEI
    SSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVV
    AVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG
    PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD
    RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLG
    SVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEANI
    RLPMQTSNICDTSMSVGTVGGQGIKTQQSFEMVKGGYTLDSNKGGGHQTL
    ESVKGVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEHKHCEDYVCSY
    NYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCIKK

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • DSC1
  • Full Name
  • Desmocollin 1
  • Introduction
  • The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.
  • Alternative Names
  • DSC1; CDHF1; DG2/DG3; desmocollin-1; cadherin family member 1; desmosomal glycoprotein 2/3; Desmocollin 1

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