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Magic™ Membrane Protein Human DSC1 (Desmocollin 1) Expressed in NS0 for Antibody Discovery, Partial (135-686aa) (CAT#: MPX0702K)

This product is a 63 kDa Human DSC1 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DSC1
  • Protein Length
  • Partial (135-686aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 63 kDa
  • TMD
  • 1
  • Sequence
  • RWAPIPASLMENSLGP
    FPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSI
    DREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFT
    VPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT
    GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDN
    PPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNEN
    GNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQT
    PTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEI
    SSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVV
    AVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG
    PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD
    RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPN

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 400 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • DSC1
  • Full Name
  • Desmocollin 1
  • Introduction
  • The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.
  • Alternative Names
  • DSC1; CDHF1; DG2/DG3; desmocollin-1; cadherin family member 1; desmosomal glycoprotein 2/3; Desmocollin 1

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