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Magic™ Membrane Protein Human DSG1 (Desmoglein 1) Expressed in NS0 for Antibody Discovery, Partial (50-545aa) (CAT#: MPX0244K)

Datasheet
This product is a 82 kDa Human DSG1 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DSG1
  • Protein Length
  • Partial (50-545aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 82 kDa
  • TMD
  • 1
  • Sequence
  • E
    WIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIF
    VINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDI
    NDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIR
    QEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMS
    AECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS
    ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIG
    VRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS
    NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTK
    EQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKI
    TTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVH

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in Tris, NaCl and Citrate.

Target

  • Target Protein
  • DSG1
  • Full Name
  • Desmoglein 1
  • Introduction
  • This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
  • Alternative Names
  • DSG1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; desmoglein-1; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen; Desmoglein 1

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