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Magic™ Membrane Protein Human EIF2AK3 (Eukaryotic translation initiation factor 2 alpha kinase 3) Full Length (CAT#: MPC1669K) Made to Order

This product is a 125.2 kDa Human EIF2AK3 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • EIF2AK3
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • Molecular Weight
  • 125.2 kDa
  • TMD
  • 1
  • Sequence
  • MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAA
    AAPTSATRVPAAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRP
    RGRSLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGN
    KMIIPSLDGALFQWDQDRESMETVPFTVESLLESSYKFGDDVVLVGGKSL
    TTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQRTQKTVRAVGP
    RSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
    QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKV
    IPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSS
    VRISEKFPSSPKALESVTNENAIIPLPTIKWKPLIHSPSRTPVLVGSDEF
    DKCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRF
    LDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIVRRLFHPHPHR
    QRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
    RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG
    IVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRM
    DPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHED
    ISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRE
    RTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSE
    ATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
    NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV
    VKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS
    YSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCE
    YVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGT
    KHSRQSNNSHSPLPSN

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • EIF2AK3
  • Full Name
  • Eukaryotic translation initiation factor 2 alpha kinase 3
  • Introduction
  • The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
  • Alternative Names
  • EIF2AK3; PEK; WRS; PERK; eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; pancreatic EIF2-alpha kinase; truncated eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2 alpha kinase 3

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