Magic™ Membrane Protein Human EPHB2 (EPH receptor B2) Expressed in NS0 for Antibody Discovery, Partial (19-543aa) (CAT#: MPX0150K)

Datasheet

This product is a 84.7 kDa Human EPHB2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
EPHB2

Protein Length
Partial (19-543aa)

Protein Class
Receptor

Molecular Weight
84.7 kDa

Sequence
VEETLMDSTTATAELGWMVHPPSGWEEVSGYD
ENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSI
PSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQV
DLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRI
IQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVP
IGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA
TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDS
GGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLA
HTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVD
SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKA
GAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPL

Product Description

Expression Systems
NS0

Tag
hIgG1 Fc tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 200 μg/mL in sterile PBS.

Endotoxin
<1.0 EU per 1 μg of the protein by the LAL method.

Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
EPHB2

Full Name
EPH receptor B2

Introduction
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants.

Alternative Names
EPHB2; DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; BDPLT22; ephrin type-B receptor 2; EPH-like kinase 5; developmentally-regulated Eph-related tyrosine kinase; elk-related tyrosine kinase; eph tyrosine kinase 3; protein-tyrosine kinase HEK5; renal carcinoma antigen NY-REN-47; tyrosine-protein kinase TYRO5; tyrosine-protein kinase receptor EPH-3; EPH receptor B2

Gene ID
2048

UniProt ID
P29323

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