Magic™ Membrane Protein Human F3 (Coagulation factor III, tissue factor) Expressed in E.coli with 6xHis and SUMO tag at the N-terminus for Antibody Discovery, Partial (33-251aa) (CAT#: MPX4291K)

Datasheet

This product is a 40.8kDa Human F3 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
F3

Protein Length
Partial (33-251aa)

Protein Class
Receptor

Molecular Weight
40.8kDa

Sequence
SGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFRE

Product Description

Expression Systems
E.coli

Tag
6xHis and SUMO tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
F3

Full Name
Coagulation factor III, tissue factor

Introduction
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Alternative Names
TF; TFA; CD142; tissue factor; coagulation factor III (thromboplastin, tissue factor)

Gene ID
2152

UniProt ID
P13726

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