Magic™ Membrane Protein Human FGFRL1 (Fibroblast growth factor receptor like 1) Expressed in HEK293 for Antibody Discovery, Partial (25-378aa) (CAT#: MPX0441K)

Datasheet

This product is a 40 kDa Human FGFRL1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
FGFRL1

Protein Length
Partial (25-378aa)

Protein Class
Receptor

Molecular Weight
40 kDa

Sequence
ARGPPKMADKVVPRQVARLGRTVRLQ
CPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCK
ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFT
QPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR
KKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTG
THPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRS
AFLTVLPDPKPPGPPVASSSSATSLPWP

Product Description

Activity
Yes

Expression Systems
HEK293

Tag
6xHis tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 500 μg/mL in PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
FGFRL1

Full Name
Fibroblast growth factor receptor like 1

Introduction
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Alternative Names
FGFRL1; FHFR; FGFR5; FGFR-5; FGF homologous factor receptor; FGF receptor-like protein 1; FGFR-like protein; fibroblast growth factor receptor 5; Fibroblast growth factor receptor like 1

Gene ID
53834

UniProt ID
Q8N441

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