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This product is a made-to-order Human FUT3 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)
Target
Target Protein
FUT3
Full Name
Fucosyltransferase 3 (Lewis blood group)
Introduction
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection.
Alternative Names
FUT3; LE; Les; FT3B; CD174; FucT-III; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; Lewis FT; alpha-(1,3/1,4)-fucosyltransferase; alpha-3-fucosyltransferase FUT3; blood group Lewis alpha-4-fucosyltransferase; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); fucosyltransferase III; galactoside 3(4)-L-fucosyltransferase; truncated fucosyltransferase 3; Fucosyltransferase 3 (Lewis blood group)